Dimethyl Sulfoxide
Medchemexpress LLC Azd4320 10Mm 1Ml Dmso Reconst | HY112416-10MM-1ML RECONST
Azd4320 10Mm 1Ml Dmso Reconst
Apexbio Technology LLC Bosutinib (SKI-606)(Synonyms: SKI-606, Bosulif, SKI606, Bosutinib monohydrate), 10mM (in 1mL DMSO), CAS: 380843-75-4.
Bosutinib (SKI-606 CAS 380843-75-4) is a dual inhibitor targeting c-Src and Abl kinases with IC50 values of approximately 1 2 nM and 1 nM respectively It suppresses phosphorylation of Bcr-Abl Src and Stat5 in chronic myeloid leukemia (CML) cells thereby decreasing proliferation and inducing regression in K562 xenograft tumor models Bosutinib also reduces Src autophosphorylation and inhibits -catenin signaling by blocking its interaction with TCF4 transcription factor consequently downregulating cyclin D1 expression in colorectal cancer cells This mechanism results in decreased cell motility and enhanced -catenin binding to E-cadherin highlighting utility in cancer research
Apexbio Technology LLC Ulipristal 159811-51-5 10mM (in 1mL DMSO)
Ulipristal is a selective progesterone receptor modulator (SPRM) exhibiting tissue-specific agonist and antagonist activities on progesterone-sensitive targets It functions through competitively binding to the progesterone receptor thereby modulating downstream cellular and physiological responses Ulipristal has been explored in biomedical research primarily for emergency contraception administered within 120 hours following unprotected intercourse Additionally ulipristal demonstrates potential utility in managing benign gynecological disorders such as uterine fibroids (leiomyomas) by mediating apoptosis in myomatous cells and controlling cellular proliferation In vitro studies indicate that ulipristal acetate inhibits progesterone-stimulated acrosome reactions and hyperactivation of human spermatozoa highlighting its potential receptor-mediated modulation of sperm functions
Apexbio Technology LLC Anidulafungin(Synonyms: Eraxis, Ecalta, LY303366, VER-002, Anidulafungin acetate, V-echinocandin, Vicuron echinocandin), 10mM (in 1mL DMSO), CAS: 166663-25-8.
Anidulafungin (CAS 166663-25-8) also known as LY-303366 is a semisynthetic derivative of echinocandin B exhibiting antifungal activity It acts by inhibiting fungal cell wall synthesis through interference with the enzyme -(1 3)-D-glucan synthase In vitro analyses demonstrate that Anidulafungin inhibits various Candida species including C albicans C glabrata C tropicalis and C parapsilosis (MIC90 0 08 0 32 0 32 5 12 g/ml respectively) as well as Aspergillus species (MIC90 0 02 g/ml) Lack of significant efficacy was shown against Cryptococcus neoformans and Blastomyces dermatitidis This compound is useful for research exploring antifungal resistance mechanisms and therapeutics
Apexbio Technology LLC BMS-777607 1025720-94-8 10mM (in 1mL DMSO)
BMS-777607 (CAS 1025720-94-8) is an orally bioavailable ATP-competitive inhibitor targeting MET kinase and related receptor tyrosine kinases It selectively inhibits members of the MET family including RON MET Tyro-3 and Axl with IC50 values of 1 8 nmol/L 3 9 nmol/L 4 3 nmol/L and 1 1 nmol/L respectively At higher doses it also inhibits additional tyrosine kinases such as Mer Flt-3 Aurora B Lck and VEGFR2 BMS-777607 has been shown to suppress c-Met autophosphorylation (IC50 20 nmol/L) thereby impairing tumor xenograft growth and metastatic phenotypes supporting its utility in oncological research models exploring MET-driven tumorigenesis and cancer progression
Apexbio Technology LLC PCI-24781 (CRA-024781) 783355-60-2 10mM (in 1mL DMSO)
PCI-24781 (CRA-024781 CAS 783355-60-2) is a histone deacetylase (HDAC) inhibitor targeting HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 and HDAC10 with reported Ki values of 7 19 8 2 17 280 and 24 nM respectively HDAC enzymes catalyze the removal of acetyl groups from lysine residues on histone proteins thereby regulating chromatin structure and gene expression PCI-24781 induces dose-dependent hyperacetylation of histones and tubulin in human cancer cells (HCT116 DLD-1) leading to apoptosis via p21 upregulation PARP cleavage and H2AX accumulation PCI-24781 demonstrates antitumor activity against multiple tumor cell lines and in xenograft models highlighting its utility for oncology research
Apexbio Technology LLC OTX-015 202590-98-5 10mM (in 1mL DMSO)
OTX-015 (CAS 202590-98-5) is a selective inhibitor of BRD2 BRD3 and BRD4 proteins within the BET (bromodomain and extra-terminal) family involved in transcriptional regulation By disrupting the interaction between these BRD proteins and acetylated histone H4 OTX-015 exhibits inhibitory activity demonstrated by IC50 values between 92 and 112 nM and in vitro EC50 ranging from 10 to 19 nM OTX-015 treatment reduces proliferation (GI50 60 200 nM) induces G1 arrest and promotes apoptosis in various human cancer cell models In xenograft mouse studies of BRD-NUT midline carcinoma orally administered OTX-015 significantly suppresses tumor growth showing potential utility for cancer research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydrous, >=99.9% | 67-68-5 | MFCD00002089 | 2L
Dimethyl sulfoxide anhydrous, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 2L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 18L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 18L