Dimethyl Sulfoxide
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 500ML
NC3885792 DIMETHYL SULFOXIDE 500ML
Apexbio Technology LLC Dopamine HCl 62-31-7 10mM (in 1mL DMSO)
Dopamine HCl (CAS 62-31-7) is a catecholamine neurotransmitter that functions as an endogenous agonist at dopamine receptors (subtypes D1 D5) Mechanistically dopamine activates these G protein-coupled receptors modulating neurotransmission and influencing diverse physiological processes such as motor control cognition motivation and neuroendocrine regulation In biomedical research dopamine HCl serves as a standard reagent for investigating dopaminergic signaling pathways receptor pharmacology and the molecular basis of neurological disorders
Apexbio Technology LLC FK866 (APO866) 658084-64-1 10mM (in 1mL DMSO)
FK866 (APO866 CAS 658084-64-1) is a small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme involved in NAD biosynthesis FK866 inhibits NMPRTase with reported IC50 values ranging from 0 09 to 27 2 nM Due to elevated NAD turnover in cancer cells inhibition of NAD synthesis selectively induces cell death in cancerous cells FK866 reduces ATP production by decreasing cellular NAD availability resulting in mitochondrial membrane depolarization and caspase-independent cell death Preclinical studies demonstrate activity against hematologic cancer cell lines including AML with minimal toxicity to normal hematopoietic progenitors FK866 suppresses tumor growth in vivo and prolongs survival making it useful in oncology research related to NAD metabolism
Apexbio Technology LLC RG 108 48208-26-0 10mM (in 1mL DMSO)
RG 108 (CAS 48208-26-0) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) It acts by directly blocking DNMT activity without forming covalent enzyme-adducts leading to DNA demethylation and consequent reactivation of epigenetically silenced tumor suppressor genes However RG 108 treatment does not affect methylation status of centromeric satellite DNA sequences In cellular models RG 108 promotes reprogramming efficiency especially enhancing induction of pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs) It is useful for studying epigenetic gene regulation tumor suppression pathways and cellular reprogramming mechanisms
Apexbio Technology LLC MLN4924 905579-51-3 10mM (in 1mL DMSO)
MLN4924 (CAS 905579-51-3) is a selective inhibitor targeting NEDD8-activating enzyme (NAE) exhibiting an IC50 of 4 nM It acts competitively against AMP binding within the nucleotide-binding pocket of NAE with strong specificity over related enzymes UAE SAE UBA6 and ATG7 (IC50 1 5 M) In HCT-116 cells MLN4924 reduces Ubc12-NEDD8 and cullin-NEDD8 conjugation disrupting CRL-mediated ubiquitination and thus stabilizing substrates such as CDT1 resulting in cell cycle defects MLN4924 shows antitumor efficacy in HCT-116 H522 and Calu-6 tumor xenograft models highlighting its research utility in cancer biology
Apexbio Technology LLC Rifapentine 61379-65-5 10mM (in 1mL DMSO)
Rifapentine is an antibiotic compound employed in the treatment of pulmonary tuberculosis an infectious disease primarily caused by Mycobacterium tuberculosis Rifapentine inhibits bacterial RNA polymerase thereby preventing RNA synthesis essential for bacterial replication and survival In vitro studies demonstrate that rifapentine possesses potent activity against intracellular M tuberculosis residing within human macrophages with reported MIC values ranging from 0 015 to 0 06 mg/ml Preclinical research indicates rifapentine accumulates extensively in host cells achieving higher intracellular concentrations than structurally related rifampin Clinically rifapentine administration schedules involve twice-weekly doses during the intensive phase of tuberculosis therapy followed by weekly dosing in the continuation phase Rifapentine is commonly investigated in pharmacological studies to assess efficacy and optimize dosing regimens in pulmonary tuberculosis treatment
Apexbio Technology LLC PCI-24781 (CRA-024781) 783355-60-2 10mM (in 1mL DMSO)
PCI-24781 (CRA-024781 CAS 783355-60-2) is a histone deacetylase (HDAC) inhibitor targeting HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 and HDAC10 with reported Ki values of 7 19 8 2 17 280 and 24 nM respectively HDAC enzymes catalyze the removal of acetyl groups from lysine residues on histone proteins thereby regulating chromatin structure and gene expression PCI-24781 induces dose-dependent hyperacetylation of histones and tubulin in human cancer cells (HCT116 DLD-1) leading to apoptosis via p21 upregulation PARP cleavage and H2AX accumulation PCI-24781 demonstrates antitumor activity against multiple tumor cell lines and in xenograft models highlighting its utility for oncology research
Apexbio Technology LLC Fluoxetine HCl(Synonyms: Prozac, Sarafem, Fluoxetine Hydrochloride, Lilly 110140, Fluoxeren, Fluctin), 10mM (in 1mL DMSO), CAS: 56296-78-7.
Fluoxetine HCl (CAS 56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) that specifically blocks presynaptic serotonin (5-HT) transporters resulting in elevated extracellular serotonin levels It modulates serotonergic signaling through inhibition of serotonin-induced membrane currents in cloned 5HT2C receptors exhibiting an IC50 around 20 M and binds 5HT2C receptors expressed in HeLa cells (Ki approximately 65-97 nM) Fluoxetine treatment has been shown in vivo to stimulate neurogenesis and enhance neuronal maturation and synaptic plasticity within rat hippocampus and prefrontal cortex Widely employed in neuroscience research fluoxetine aids in studies of depression stress resilience and neuro-regulatory mechanisms involving serotonergic signaling